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Disregarding the men who reported most inadequately, a clear correlation was evident between the proportion of linoleic acid in adipose tissue and the food diaries. After taking statistical account of a number of known risk factors for cardiovascular disease, no clear correlations with cardiovascular disease were observed for any fatty acid (251 deaths during a 15-year follow-up period). Measuring the fatty acid composition of adipose tissue can therefore make a valuable contribution to our knowledge about the association between diet and disease. Overall, the findings indicate that the proportion of polyunsaturated fatty acids in adipose tissue reflects the individual’s intake of these fatty acids over the long term, and this appears to be particularly true of linoleic acid, which is the most common polyunsaturated fatty acid. The findings may further indicate that an excessively low intake of polyunsaturated fatty acids increases the risk of (premature) death. Somewhat weaker correlations were observed between fatty acids in the blood and reported intake, while strong correlations were observed between adipose tissue and blood for most fatty acids. PDGFB from platelets was found to be essential, to attract supporting cells to the tumor blood vessels.
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